From the site of the US Treasury 

http://www.treas.gov/education/faq/currency/denominations.shtml

Question: What denominations of currency are in circulation today? Will any new denominations be produced?

Answer:  The present denominations of our currency in production are $1, $2, 5$, $10, $20, $50 and $100. The purpose of the United States currency system is to serve the needs of the public and these denominations meet that goal. Neither the Department of the Treasury nor the Federal Reserve System has any plans to change the denominations in use today.



                                                                    *************

Question:  What was the largest currency denomination ever produced?

Answer:  The largest denomination of currency ever printed by the Bureau of Engraving and Printing (BEP) was the $100,000 Series 1934 Gold Certificate featuring the portrait of President Wilson. These notes were printed from December 18, 1934 through January 9, 1935 and were issued by the Treasurer of the United States to Federal Reserve Banks only against an equal amount of gold bullion held by the Treasury Department. The notes were used only for official transactions between Federal Reserve Banks and were not circulated among the general public.

The $100,000 dollar bill is actually not a dollar bill at all, it's a gold certificate. What's a gold certificate? Well a gold certificate is money that the government prints that only they can own and use. It is intended for only the use in Fiscal Channels. They were never issued or used for general circulation. This specific gold certificate was printed in 1934 and has the 28th president, Woodrow Wilson's portrait on it. There were only 42,000 $100,000 dollar certificates printed and the only ones around today are not for sale and are used for educational purposes only. The few remaining undestroyed $100,000 certificates are institutionalized today and may be seen only in some museums.
                                                                  **************

Question:  What denominations of currency notes is the Treasury Department no longer printing?

Answer:  On July 14, 1969, David M. Kennedy, the 60th Secretary of the Treasury, and officials at the Federal Reserve Board announced that they would immediately stop distributing currency in denominations of $500, $1,000, $5,000 and $10,000. Production of these denominations stopped during World War II. Their main purpose was for bank transfer payments. With the arrival of more secure transfer technologies, however, they were no longer needed for that purpose. While these notes are legal tender and may still be found in circulation today, the Federal Reserve Banks remove them from circulation and destroy them as they are received.

                                                                ******************

Question:  Did the Treasury Department ever produce a $1 million currency note? I have one that I want to know about.

Answer:  We receive many inquiries asking if the Treasury Department ever produced a $1 million currency note. People have sent in copies of these notes. We have found that they are nonnegotiable platinum certificates known as a "One Million Dollar Special Issue." These notes were from a special limited copyrighted art series originally sold by a Canadian firm for $1.00 each as a collectible item. They are not official United States currency notes manufactured by our Bureau of Engraving and Printing (BEP). As such, they are not redeemable by the Department of the Treasury.

You may be interested to know that the BEP learned of these certificates in the spring of 1982. All related correspondence was forwarded to the United States Secret Service to decide if there were any violations of Federal currency laws. The Secret Service subsequently advised, however, that these certificates did not violate any United States law.

                                                                         **************

Question: Why did the Treasury Department remove the $2 bill from circulation?

Answer:   The $2 bill has not been removed from circulation and is still a circulating denomination of United States paper currency. The Federal Reserve System does not, however, request the printing of that denomination as often as the others. The Series 2003 $2 bill was the last printed and bears the names of former Secretary of the Treasury John W. Snow and Treasurer Rosario Marin. As of April 30, 2007 there were $1,549,052,714 worth of $2 bills in circulation worldwide.

The key for successfully circulating the $2 bill is for retailers to use them just like any other denomination in their daily operations. In addition, most commercial banks will readily supply their retail customers with these bills if their customers request them in sufficient volume to justify stocking them in their vaults. However, neither the Department of the Treasury nor the Federal Reserve System can force the distribution or use of any denomination of currency on banks, businesses or individuals.

                                                                        *******************

$500 to $1,000 to $10,000 and Beyond: The Biggest Dollar Bills in United States History

 

Yes, it may be hard to believe but the U.S. government did print $500 dollar bills for the general public at one point in history. This specific $500 dollar bill was printed in 1928 and features a portrait of the twenty- fifth President William McKinley. Today, there are very few of these $500 bills left. Nowadays they are collectors' items and sell for thousands. The funny thing is that they still could be used in stores today, because by law they are still U.S. currency. If you are interested in buying $500 bills you can find them for sale online.

The United States government also printed $1,000 dollar bills which circulated in the American general public. This specific $1,000 dollar bill was printed in 1928 and has the portrait of the twenty-fourth president Grover Cleveland printed on. The $1,000 dollar bills are also collectors' items and can be found for sale online. The 1,000 dollar bill and all bills over $100 were printed until 1946 before they were discontinued. They were then allowed to circulate in the general public until 1969 were they were recalled. The only remaining $1,000 dollar bills are the ones that were not turned in on the recall. There are very few bills left and are all worth thousands of dollars.

The United States government also printed a $5,000 dollar bill which circulated in the American general public until 1969 when it was recalled. This specific $5,000 dollar bill was printed in 1934 and contains the portrait of the fourth president of the United States James Madison printed on it. There are less then five hundred $5,000 bills remaining in the world and if you are looking to buy one, check online. This site has very many old dollar bills that are for sale and is a dream website for any modern day collector.

The $10,000 dollar bill was the largest of all dollar bills that was printed and circulated in the American general public. This specific dollar bill was printed in 1934 and contains the portrait of U.S. Treasury Secretary Chase printed on it. These bills were also recalled in 1969 and very few are still around today. The $10,000 dollar bill is also a collectible and can be bought online. But don't expect one of these babies to come cheap, be ready to leave a dent in your wallet and fork out over 10 grand. If I were I wouldn't spend one of these in a store. These bills would only be for the hardcore collectors.